A Population-Based Ultra-Widefield Digital Image Grading Study for Age-Related Macular Degeneration-Like Lesions at the Peripheral Retina.

Our understanding of the relevance of peripheral retinal abnormalities to disease in general and in age-related macular degeneration (AMD) in particular is limited by the lack of detailed peripheral imaging studies. The purpose of this study was to develop image grading protocols suited to ultra-widefield imaging (UWFI) in an aged population

Electron Dynamics in a Coupled Quantum Point Contact Structure with a Local Magnetic Moment

We develop a theoretical model for the description of electron dynamics in coupled quantum wires when the local magnetic moment is formed in one of the wires. We employ a single-particle Hamiltonian that takes account of the specific geometry of potentials defining the structure as well as electron scattering on the local magnetic moment. The equations for the wave functions in both wires are derived and the approach for their solution is discussed. We determine the transmission coefficient and conductance of the wire having the local magnetic moment and show that our description reproduces the experimentally observed features.Comment: Based on work presented at 2004 IEEE NTC Quantum Device Technology Worksho

Magnetorotational-type instability in Couette-Taylor flow of a viscoelastic polymer liquid

We describe an instability of viscoelastic Couette-Taylor flow that is directly analogous to the magnetorotational instability (MRI) in astrophysical magnetohydrodynamics, with polymer molecules playing the role of magnetic field lines. By determining the conditions required for the onset of instability and the properties of the preferred modes, we distinguish it from the centrifugal and elastic instabilities studied previously. Experimental demonstration and investigation should be much easier for the viscoelastic instability than for the MRI in a liquid metal. The analogy holds with the case of a predominantly toroidal magnetic field such as is expected in an accretion disk and it may be possible to access a turbulent regime in which many modes are unstable.Comment: 4 pages, 4 figures, to be published in Physical Review Letter

Microrheological Characterisation of Anisotropic Materials

We describe the measurement of anisotropic viscoelastic moduli in complex soft materials, such as biopolymer gels, via video particle tracking microrheology of colloid tracer particles. The use of a correlation tensor to find the axes of maximum anisotropy, and hence the mechanical director, is described. The moduli of an aligned DNA gel are reported, as a test of the technique; this may have implications for high DNA concentrations in vivo. We also discuss the errors in microrheological measurement, and describe the use of frequency space filtering to improve displacement resolution, and hence probe these typically high modulus materials.Comment: 5 pages, 5 figures. Replaced after refereeing/ improvement. Main results are the same. The final, published version of the paper is here http://link.aps.org/abstract/PRE/v73/e03190

Intergovernmental fiscal relations and poverty alleviation in Viet Nam

A successful poverty alleviation strategy has four distinct elements: 1) identifying who the poor are, where they are located, and what they do; 2) analyzing why they are poor; 3) developing policies to improve their standards of living; and 4) supplementing income-improving policies with direct"safety net"policies to increase the poor's short-term consumption etitlements. The precise mixture of"capacity-improving"investments and"safety net"policies appropriate for any country will depend on the country's income level, the extent and nature of its poverty problem, and many other factors. The strategy chosen must be implemented effectively. Spending and revenue decisions need to be more decentralized to ensure that the poverty alleviation policies adopted reflect the preferences, needs, and fiscal abilities of different regions of the country. The nature of that decentralization depends on the country. Pro-poor services throughout Viet Nam are underfunded. This problem is particularly acute in the poorer areas. Improvements in the system of intergovernmental finances could help ensure that each level of government, even in the poorer provinces, is adequately funded - and provided with sufficient expenditure and revenue raising autonomy - to support local investments and their operation and maintenance. Since poor provinces are less able to mobilize additional local revenues to support services, well-designed intergovernmental transfers are particularly important. Provinces must play a greater role both in raising revenues and in allocating expenditures, with incentives built in to ensure that they do so responsibly and efficiently. Local governments must - if they are tobe held accountable for their actions - have some responsibility for determining local tax rates. This will allow them to vary rates to collect more revenues to finance higher levels of public services if they so choose, and at the same time allow the central government to design its transfers in such a way as to ensure that local fiscal efforts are not discouraged by the receipt of such transfers. Richer provinces will tend to collect greater revenues. When transfers are needed to finance local spending in poorer areas, they should provide incentives for local revenue mobilization and allow for some degree of equalization. Services deemed of national importance (for example, a minimum level of education, health care, and social relief) can be promoted by designing specific-purpose transfers. These services must be identified and varying matching requirements established for different provinces depending on such factors as their own revenue base and the cost of providing services in that province.Municipal Financial Management,Public Sector Economics&Finance,Environmental Economics&Policies,Banks&Banking Reform,Decentralization,National Governance,Environmental Economics&Policies,Public Sector Economics&Finance,Health Economics&Finance,Banks&Banking Reform

Enhancing the Pierre Auger Observatory to the 10^{17} to 10^{18.5} eV Range: Capabilities of an Infill Surface Array

The Pierre Auger Observatory has been designed to study the highest-energy cosmic rays in nature (E > 10^{18.5} eV). The determination of their arrival direction, energy and composition is performed by the analysis of the atmospheric showers they produce. The Auger Surface Array will consist of 1600 water Cerenkov detectors placed in an equilateral triangular grid of 1.5 km spacing. The aim of this paper is to show that the addition of a "small" area of surface detectors at half or less the above mentioned spacing would allow a dramatic increase of the physical scope of this Observatory, reaching lower energies at which the transition from galactic to extragalactic sources is expected.Comment: 21 pages, 5 figures, accepted for publication in Nucl. Instr. & Meth. in Phys. Res.

Cosmology with velocity dispersion counts: an alternative to measuring cluster halo masses

The evolution of galaxy cluster counts is a powerful probe of several fundamental cosmological parameters. A number of recent studies using this probe have claimed tension with the cosmology preferred by the analysis of the Planck primary CMB data, in the sense that there are fewer clusters observed than predicted based on the primary CMB cosmology. One possible resolution to this problem is systematic errors in the absolute halo mass calibration in cluster studies, which is required to convert the standard theoretical prediction (the halo mass function) into counts as a function of the observable (e.g., X-ray luminosity, Sunyaev-Zel'dovich flux, optical richness). Here we propose an alternative strategy, which is to directly compare predicted and observed cluster counts as a function of the one-dimensional velocity dispersion of the cluster galaxies. We argue that the velocity dispersion of groups/clusters can be theoretically predicted as robustly as mass but, unlike mass, it can also be directly observed, thus circumventing the main systematic bias in traditional cluster counts studies. With the aid of the BAHAMAS suite of cosmological hydrodynamical simulations, we demonstrate the potential of the velocity dispersion counts for discriminating even similar $\Lambda$CDM models. These predictions can be compared with the results from existing redshift surveys such as the highly-complete Galaxy And Mass Assembly (GAMA) survey, and upcoming wide-field spectroscopic surveys such as the Wide Area Vista Extragalactic Survey (WAVES) and the Dark Energy Survey Instrument (DESI).Comment: 15 pages, 13 figures. Accepted for publication in MNRAS. New section on cosmological forecasts adde

Shell Model of Two-dimensional Turbulence in Polymer Solutions

We address the effect of polymer additives on two dimensional turbulence, an issue that was studied recently in experiments and direct numerical simulations. We show that the same simple shell model that reproduced drag reduction in three-dimensional turbulence reproduces all the reported effects in the two-dimensional case. The simplicity of the model offers a straightforward understanding of the all the major effects under consideration

Association of drusen deposition with choroidal intercapillary pillars in the aging human eye

PURPOSE. To determine the pattern of drusen accumulation with age and to investigate the initial sites of deposition and their relationship to choroidal capillaries in human donor eyes from the eye bank of Moorfields Eye Hospital.METHODS. Wholemounted, hydrated preparations of the choriocapillaris and Bruch's membrane from donor eyes ranging from 42 to 95 years, with or without retinal pigment epithelium (RPE), were examined by conventional and confocal microscopy. Drusen were visualized by their autofluorescence.RESULTS. In all age groups studied autofluorescent drusen were present at the equator but were not found centrally where the vascular architecture is different, being tubular rather than a honeycomb pattern. Autofluorescing drusen were strongly associated with the lateral walls of the choriocapillaris (an area commonly known as the intercapillary pillars of the choriocapillaris (P = 0.028; Wilcoxon signed ranks test). Nonfluorescing drusen were occasionally seen centrally, but were not easily identified, and because of their large size, their localization with respect to capillary walls was not possible.CONCLUSIONS. These results strongly support the notion that autofluorescent drusen are not randomly distributed and have a specific spatial relationship to choroidal vessel walls. That equatorial drusen fluoresce, whereas central drusen do not, suggests that they may have different chemical compositions at the two sites and possibly different significance in age-related macular disease

Supersymmetry solution for finitely extensible dumbbell model

Exact relaxation times and eigenfunctions for a simple mechanical model of polymer dynamics are obtained using supersymmetry methods of quantum mechanics. The model includes the finite extensibility of the molecule and does not make use of the self-consistently averaging approximation. The finite extensibility reduces the relaxation times when compared to a linear force. The linear viscoelastic behaviour is obtained in the form of the ``generalized Maxwell model''. Using these results, a numerical integration scheme is proposed in the presence of a given flow kinematics.Comment: 5 pages, 2 figure